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KMID : 0043320100330010071
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Archives of Pharmacal Research
2010 Volume.33 No. 1 p.71 ~ p.74
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Cytotoxic Germacranolide Sesquiterpenes from the Bark of Magnolia kobus
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Kim Dae-Keun
Lee Jae-Hyeok
Yang Jae-Heon
Choi Sang-Un
Park Hee-Wook
Baek Nam-In
Kim Sung-Hoon
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Abstract
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A new (3) and three known germacrane-type sesquiterpenoids were isolated from the chloroform-soluble fraction of the methanolic extract of the bark of Magnolia kobus (Magnoliaceae) through repeated silica gel and Sephadex LH-20 column chromatography. Their chemical structures were elucidated as costunolide (1), parthenolide (2), isobisparthenolidine (3), and bisparthenolidine (4) by spectroscopic analysis. Compounds 1-4 exhibited cytotoxicity against human A549, SK-OV-3, SK-MEL-2, and HCT15 tumor cells.
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KEYWORD
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Magnolia kobus, Magnoliaceae, Sesquiterpenoid, Cytotoxicity
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